Description

MOTS-c — Mitochondrial-Derived Research Peptide

Scientific Overview

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a naturally occurring mitochondrial-derived peptide composed of 16 amino acids. It is encoded within a short open reading frame located in the mitochondrial 12S rRNA region and has become an important research subject in mitochondrial biology, cellular energetics, metabolic signaling, and adaptive stress-response pathways.

MOTS-c is scientifically distinctive because it originates from mitochondrial genetic material rather than from a conventional nuclear protein-coding gene. Research has examined its relationship with cellular energy sensing, metabolic homeostasis, mitochondrial-to-nuclear communication, and AMPK-associated signaling pathways.

Its unusual mitochondrial origin makes MOTS-c particularly relevant for laboratory investigations exploring how mitochondria function not only as energy-producing organelles, but also as components of complex intracellular signaling networks.

Key Characteristics

Compound: MOTS-c
Full Name: Mitochondrial Open Reading Frame of the Twelve S rRNA-c
Peptide Length: 16 amino acids
Sequence: MRWQEMGYIFYPRKLR
Molecular Weight: Approximately 2,174.6 Da
Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
CAS Number: 1627580-64-6
Biological Classification: Mitochondrial-Derived Peptide (MDP)
Genetic Origin: Mitochondrial 12S rRNA region
Format: Lyophilized peptide
Research Category: Mitochondrial & Metabolic Signaling Research
Application: Laboratory and analytical research only

Research Focus

MOTS-c has been investigated in preclinical research involving:

• Mitochondrial signaling and biology
• Cellular energy metabolism
• Metabolic homeostasis
• AMPK-associated signaling
• Cellular energy sensing
• Nutrient-response pathways
• Mitochondrial-to-nuclear communication
• Metabolic stress responses
• Exercise-related cellular signaling
• Age-associated metabolic pathways

Scientific Significance

MOTS-c belongs to the emerging class of mitochondrial-derived peptides—small signaling peptides encoded by mitochondrial genetic sequences.

The discovery of these peptides has expanded scientific interest in mitochondria beyond their traditional role in ATP production. Current research increasingly examines mitochondria as signaling organelles capable of participating in communication with wider cellular systems.

MOTS-c provides researchers with a useful subject for investigating the relationship between mitochondrial signaling, cellular energy regulation, metabolic adaptation, and stress-response mechanisms.

Research-Grade Format

MOTS-c is supplied as a lyophilized peptide intended exclusively for controlled laboratory and analytical research.

Batch-specific analytical documentation, including applicable identity and purity information, should be referenced through the corresponding Certificate of Analysis.

View COA 

Research Use Only

For laboratory, analytical, and research purposes only.

Not for human or veterinary use, ingestion, consumption, diagnosis, treatment, prevention, or mitigation of any disease or medical condition.

Purchasers and researchers are responsible for ensuring that possession, handling, and research use comply with applicable laws, institutional requirements, and laboratory safety procedures.

 

This compound is available exclusively for in vitro laboratory research and scientific study conducted within Canada. It is not a drug, natural health product, or food product as defined under the Food and Drugs Act (R.S.C., 1985, c. F-27). It is not approved for human consumption, veterinary use, or any diagnostic or therapeutic application. This product has not been evaluated by Health Canada. Researchers are responsible for compliance with all applicable federal, provincial, and local regulations.